Why conventional medications are not successful to treat joint dysfunction?
Current Medical treatment of arthritis and other joint dysfunction is largely limited to the use of steroidal or non-steroidal anti-inflammatory analgesic drugs (NSAIDs). These pharmaceutical products present serious problems during chronic administration and their use must be carefully monitored to avoid toxic effects. Also, they offer only temporary pain relief without treating the root cause of the arthritic condition. Even moderate doses of such synthetic steroids as cortisone, prednisone and dexamethasone adversely affect the body causing serious toxicity.
Why niacin and niacinamide are superior to other nutritional treatments of joint dysfunction?
Niacin and niacinamide showed success in early studies (1,2,3,4). They are precursors of nicotine-adenine-dinucleotide (NAD+) and reduced nicotine-adenine-dinucleotide (NADH). It is not yet understood which underlying biochemical action(s) responsible for the observed anti-inflammatory and pain relief of these biochemicals. However, it is well documented in the scientific literature that NAD+ and NADH are involved in hundreds of biochemical reactions in the body, including the observed pain relieving effects.
In a scientific publication William Kaufman MD PhD described his observations on over 450 patients (1). Pain and inflammation relief was observed even in older people in their 70s and 80s during niacinamide therapy. He conducted objective measurements of joint flexibility and muscle strength to fallow improvement during his long term niacinamide treatment. The most consistent diagnostic symptoms in arthritis and other joint dysfunctions are inflammation induced pain. In Dr. Kaufman’s studies improvement was objectively measured also by erythrocyte sedimentation rate (ESR). This blood test detects and measures the magnitude of inflammation in the body The ESR returned towards normal levels while taking niacinamide. Along with ESR improvement, pain relief and increased joint flexibility was reported. However if the patients stopped the niacinamide regimen, the early symptoms returned, such as pain, decreased joint flexibility and abnormal ESR levels.
Kaufman kept meticulous records of these observations in his book (1). He was using commercially available niacinamide alone and in some patients, also B and C vitamins. He reported excellent improvement controlling pain, inflammation, joint flexibility and muscle strength in both rheumatoid-arthritis and osteoarthritis patients (1,2,3,4). Kaufman’s most important observations to achieve treatment success was that instead of taking a large niacinamide dose once a day, several smaller doses during the day were much more effective. Niacinamide and niacin are highly water soluble substances, and they are quickly excreted from the body. To keep effective levels in the body, frequent smaller doses were preferable. He indicated that both osteoarthritis and rheumatoid arthritis responded well to his therapy indicating that especially in osteoarthritis some joint rebuilding also occurred.
Once pain relief and increased joint flexibility were achieved, some patients decided to stop niacinamide intake, resulting in the return of pain and inflammation. Therefore continuous treatment with niacinamide and/or niacin is necessary.
Do recent studies on niacin and niacinamide confirm the earlier observations?
In the 2006 edition of the Frontiers in Bioscience Ying W. stated that “NAD+ and NADH play critical role in energy metabolism. Also, these molecules are mediators of multiple biological processes including protein synthesis and aging.” His “…latest studies have shown that intranasal NAD+ can profoundly decrease ischemic brain damage”, when given shortly after a stroke. “These new pieces of information have fundamentally changed our understanding about NAD+ and NADH, suggesting novel paradigms about the metabolism and biological activities of NAD+ and NADH. Based on this information, it is tempted to hypothesize that NAD+ and NADH can significantly affect nearly all major biological processes. Future studies on NAD+ and NADH may not only elucidate some fundamental mysteries in biology but also provide novel insights for interfering aging and many disease processes.”
The Harvard Medical School published an article about relation between aging and NAD. They wrote: “The researchers are now looking at the longer-term outcomes of the NAD-producing compound in mice and how it affects the mouse as a whole. They are also exploring whether the compound can be used to safely treat rare mitochondrial diseases or more common diseases such as Type 1 and Type 2 diabetes. Longer term, Sinclair plans to test if the compound will give mice a healthier, longer life.” (A New—and Reversible—Cause of Aging).
This article explains in plain language the function of NAD in billions of cells in the human body. This is in Verebey Joint Support. The Journal of Clinical Investigation’s article wrote: “Despite advances in clinical therapy, metastasis remains the leading cause of death in breast cancer patients. Mutations in mitochondrial DNA, including those affecting complex I and oxidative phosphorylation, are found in breast tumors and could facilitate metastasis. This study identifies mitochondrial complex I as critical for defining an aggressive phenotype in breast cancer cells. Specific enhancement of mitochondrial complex I activity inhibited tumor growth and metastasis through regulation of the tumor cell NAD+/NADH redox balance, mTORC1 activity, and autophagy. Conversely, nonlethal reduction of NAD+ levels by interfering with nicotinamide phosphoribosyltransferase expression rendered tumor cells more aggressive and increased metastasis. The results translate into a new therapeutic strategy: enhancement of the NAD+/NADH balance through treatment with NAD+ precursors inhibited metastasis in xenograft models, increased animal survival, and strongly interfered with oncogene-driven breast cancer progression in the MMTV-PyMT mouse model. Thus, aberration in mitochondrial complex I NADH dehydrogenase activity can profoundly enhance the aggressiveness of human breast cancer cells, while therapeutic normalization of the NAD+/NADH balance can inhibit metastasis and prevent disease progression.” The Verebey Joint Support’s main ingredient is niacin. Niacin is precursor of nicotine-adenine-dinucleotide (NAD+).
Green at.al. in 2010 observed that niacinamide prevented and treated Alzheimer disease in experimental animals . Currently Dr. Green and his staff at the University Of California School Of Medicine at Irvine are conducting clinical trials with niacinamide in Alzheimer patients. This trial is to confirm their earlier findings in animal studies (6).
Dr. Verebey’s personal experience and research using niacin and niacinamide
Dr. Verebey and his colleague, Dr. Richard Koppel, a dentist, studied for 20 years the published observations of Karl Pfeifer MD, PhD (7) and, the forgotten meticulous work of William Kaufman MD, PhD (4). They used either niacin or niacinamide alone or combination to treat successfully joint pain as well as cardio-vascular problems.
Based on our decades long studies, a patent certificate were filed and accepted by the US Patent Office in 1994, titled:”Treatment of Arthritic Conditions: A new approach to treating arthritic conditions on a long-term basis without adverse side effects” (8). The patent described some of our early research, using commercially available nutritional supplements. The main ingredients were niacin and ascorbic acid.
The patent described complete relief or significant improvement in 100s of individuals regardless of age or seriousness of the joint disorder, who took the commercially available nutritional combination. Dr. Koppel recommended our formula to his dental patients who had arthritis. It helped many patients regardless of age having either rheumatoid or osteoarthritis. However, the routine of taking 3 x/day 4 different pills or tablets and the “niacin flush”, observed especially during the beginning of niacin treatment, was impractical and bothersome to many patients. Therefore compliance became a major obstacle of this early form of treatment in many subjects.
The problem was salved by a noted nutritional chemist and pharmacist Andrew Szalay, who was a student of Dr. Albert Szent-Gyorgyi, a Nobel Laureate, who isolated Vitamin C in the 1930s. Twenty years of Szalay’s research in vitamin and mineral supplements led him to a special proprietary manufacturing process of nutritional supplements. This procedure resulted in a decrease in the dosages of various vitamins and minerals while achieving much better bioavailability. His procedure combines vitamins and minerals as they are present in foods, which improves their absorption.
Szalay agreed to incorporate the major active ingredients of our formula into a single tablet. The name of the new combined tablet is “Verebey’s Joint Support”, approved by the US Trade Mark Office. After testing the new all in one tablet, we found that the effective dose is 2 tablets three times a day. This recommended dosage schedule was effective to improve arthritic knee, shoulder, hip and back pains. Two major improvements of the new “all in one tablet” preparation are that the usual “niacin flush” reaction observed after pure niacin intake was absent and it was convenient to take.
The Verebey Joint Support, when taken as directed will successfully relieve the agonizing pain without side effects of people with joint pain. Considering that the estimated number of mostly elderly patients with various joint disorders associated pain just in the USA is estimated at 65 million, this tablet is a “God Sent” to prevent the suffering of patients in their “golden age” without toxic effects. Furthermore, taking this preparation preventatively, before age related joint dysfunction develops; just 2 tablets once or twice a day may prevent this common problem ever to occur.
What convinced Dr. Verebey to commercialize this joint aide?
Dr. Verebey had a personal experience. A knee injury in the gym was diagnosed as a torn medial meniscus, and was scheduled for surgery. He started the “all in one” tablets 3 times a day and in six weeks he was totally painless and cancelled surgery.
His knee is still painless many years after the injury. Many people to whom the nutritional formula was administered became painless or their condition significantly improved. The letters of thanks and appreciation energized Dr. Verebey to commercialize this product. Also, science supported the many beneficial effects of niacin and niacinamide on joints and the heart (7), Dr Verebey used niacin daily for at least 40 years for preventive purposes and the result is NO JOINT PAIN OR CARIAC PROBLEMS at age of 75.
Are there other nutritional treatments for joint dysfunctions?
Yes, there are some nutritional supplements to support arthritic joint disorders without harmful or toxic effects. Some currently used substances are: glucosamine, chondroitin, gelatin and methyl-sulfanyl-methane (MSM). They showed some ameliorating effects on joint pain. However, the pain relief was partial and inconsistent.
A Brief Background of Dr Verebey
Dr. Verebey is graduate of Cornell University Medical College specializing in Clinical Pharmacology and Biochemistry. After 15 years of research he switched to toxicology and was appointed Chief Toxicologist for the City of New York. Currently, he is Director of North Shore Medical Lab (a Clinical & Toxicology Laboratory) He is a Fellow of the American Academy of Forensic Sciences and retired member of the American Society for Pharmacology and Experimental Therapeutics.
Dr. Verebey independently from his other research activities spent over 35 years, studying various forms of treatment modalities for arthritic conditions. The effectiveness of niacin and niacinamide has been suggested by him and by others as described above, but this natural remedy was overlooked by the scientific community and the academic medical establishment. Therefore, our efforts to bring “Verebey Joint Aide” to market is timely, as it is and was supported by early observations and recent scientific studies.
1) Kaufman W., The Common Form of Joint dysfunction: Its Incidence and Treatment, 1949, Publisher, E.L. Hildreth & Company, Brattleboro, Vermont
2) Kaufman W.: The overall picture of rheumatism and arthritis, 1952, Ann Allergy, 10:308
3) Kaufman W, Niacinamide therapy for joint mobility: Therapeutic Reversal of a Common Manifestation of the Normal Aging Process, 1953, Conn State Med J., 17:584-589
4) Kaufman W., Niacinamide, a Most Neglected Vitamin, Tom Spies Memorial Lecture. J Int. Acad. Of Preventive Med. 8:5-25, 1983
5) Ying W, NAD+ and NADH in cellular functions and cell death, 2006, Frontiers in Bioscience, 11:3129-3148.
6) Green K N, Steffan J S, Martinez-Coria H, and Sun X, at.al: Nicotinamide restores Cognition in AD transgenic mice via a mechanism involving sirtuin inhibition And selective reduction of Thr 231- phosphotau, J Neuroscience, 2008 Nov 5, 28(45): 11500-11510.
7) Pfeiffer C.C., Mental and Elemental Nutrients, 1975, Arthritis and Joint Disorders, pg 453 Keats Publishing INC. New Canaan, Connecticut
8) US Patent No. 5,358,720, Koppel and Verebey Titled: Treatment of Arthritic Conditions: A new approach to treating arthritic conditions on a long-term basis without adverse side effects, October 25, 1994.
Dr. Kaufman: The Pioneering work
Please read the following article.
Read more: doctoryourself.com
Dr. Kaufman’s bibliography is posted at http://www.doctoryourself.com/biblio_kaufman.html
THE COMMON FORM OF JOINT DYSFUNCTION
by William Kaufman, M.D., Ph.D. (1949)
Copyright C 2001 Charlotte Kaufman. Reprinted with permission.
Edited by Andrew W. Saul
METHOD OF TREATMENT OF JOINT DYSFUNCTION (pages 20-29)
by William Kaufman, M.D., Ph.D.
The Common Form of Joint Dysfunction: Its Incidence and Treatment.E.L. Hildreth and Co., Brattleboro, Vermont , 1949, 228 pages.
References and Preface http://www.doctoryourself.com/kaufman11.html
About Dr. William Kaufman’s life and work
Read more: How it works?